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Irbesartan prevents angiotensin II binding towards the AT1 receptor in tissues like vascular sleek muscle as well as the adrenal gland. Irbesartan and its Lively metabolite bind the AT1 receptor with 8500 times much more affinity than they bind for the AT2 receptor.

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Blockade of your AT1 receptor eliminates the unfavorable suggestions of angiotensin II on renin secretion, however the ensuing enhanced plasma renin activity and circulating angiotensin II do not defeat the effects of irbesartan on hypertension.

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